11
May
Is Ondansetron Safe In Pregnancy. This means that the number of babies born with cleft palate. Ondansteron a 5-HT3 receptor agonist is used to treat nausea and vomiting in pregnancy. Although most often used as an antiemetic following chemotherapy ondansetron frequently is used off-label to treat nausea and vomiting during pregnancy. The authors found no evidence of harm to the unborn baby in a series of analyses of more than 600 000.
There was an increased association of 3 per 10000 of cleft palate. JAMA 2018 sought to evaluate whether ondansetron exposure during pregnancy is associated with risk of congenital malformations with. The authors found no evidence of harm to the unborn baby in a series of analyses of more than 600 000. The popular antiemetic ondansetron looked safe for pregnant women in a large study from Denmark. Ondansetron is increasingly prescribed off label for nausea and vomiting in pregnancy and a new study suggests it is safe for this indication. B1 US FDA pregnancy category.
Evaluation of experimental animal studies does not indicate direct or indirect harmful effects with respect to the development of the embryo or fetus the course of gestation and perinatal and postnatal development.
The safety of ondansetron for use in human pregnancy has not been established. There was an increased association of 3 per 10000 of cleft palate. Safety of Ondansetron in Pregnancy Nausea and vomiting is a common ailment in pregnancy affecting approximately 70 to 80 of all pregnant women. We recommend avoiding use of ondansetron in early pregnancy and discussing the potential increased risk of congenital malformations with pregnant patients before its use. Exposure to ondansetron during the first trimester of pregnancy is associated with a small increased risk of the baby having a cleft lip andor cleft palate. However as animal studies are not always predictive of human response the use of.